HIGHTIDE Pipeline

HIGHTIDE integrates expertise in disease biology, medicinal chemistry, clinical development and regulatory affairs to advance its growing pipeline of drugs. The company’s lead drug candidate, HTD1801, is a first-in-class new molecular entity, currently in Phase II trials for the treatment of primary sclerosing cholangitis (PSC), and nonalcoholic steatohepatitis (NASH). The FDA has granted HTD1801 Fast Track Designation in both diseases.

Our Pipeline

Product Proposed Indications Discovery Preclinical Phase 1 Phase 2 Phase 3
HTD1801 PSC (Primary Sclerosing Cholangitis)
NAFLD/NASH (Non-Alcoholic Fatty Liver Disease / Non-Alcoholic Steatohepatitis)
PBC
T2DM/NAFLD 1
HTD4010 Acute Pancreatitis
Cytokine Release Syndrome
HTD2802 Inflammatory Bowel Disease (IBD)
HTD1804 Diabetic Complications
HTD1805 Diabetic Complications
HTD1807 Metabolic; Chronic Liver; CNS

 

Updated on June 2021

1.Develop in China only, while other indications are developed by IMCT (International Multicenter Clinical Trial)

HTD1801

New molecular entity: ionic salt of two active moieties

PSC (Primary Sclerosing Cholangitis)
Chronic liver disease characterized by a progressive reduction or stoppage of bile flow with inflammation and fibrosis of the intrahepatic and extrahepatic bile ducts.
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NAFLD/NASH (Non-Alcoholic Fatty Liver Disease / Non-Alcoholic Steatohepatitis)
NAFLD is one of the types of fatty liver due to causes other than excessive alcohol use. NASH is the most extreme form of NAFLD.
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HTD4010

Peptide analog of RegIII/PAP protein active fragment

Acute Pancreatitis
Pancreatitis is inflammation of the pancreas.
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HTD2802

An innovative fixed dose combination of two known compounds with clear differentiation for unmet clinical needs

Inflammatory Bowel Disease (IBD)
Inflammatory bowel disease (IBD) is a general term used to describe disorders that involve chronic inflammation of the digestive tract.
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