Discovery Portfolio

The benefits of weight loss are well understood. In obese patients, weight loss ameliorates the metabolic risk factors for diabetes, coronary artery disease, and obesity-associated cancers. However, these health benefits can be compromised by weight-associated loss of lean body mass, which could increase the risk of sarcopenia, decreased mobility, increased frailty and an overall reduction in quality of life.

Activating the metabolic process of mitochondrial uncoupling is expected to result in not only muscle sparing weight loss, but also enhancement of endurance through increasing type-I muscle percentage; reduction of liver and visceral fat; improved glycemic control, and reductions in oxidative stress and inflammation.

Neurodegenerative diseases present one of the most formidable therapeutic challenges of our time. Despite decades of dedicated research, effective treatments and preventive measures remain elusive. In the context of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, Lou Gehrig’s diseases and multiple sclerosis, mitochondrial dysfunction is one of the key disease features.

Mitochondria uncouplers can help reduce oxidative stress and prevent calcium overload. This, in addition to other mechanisms that improve neuronal mitochondria health, may allow for more effective treatments in the future.